E77A (p.Glu77Ala) variant of SIRT7 (Q9NRC8)
E77A (p.Glu77Ala) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
E77A (p.Glu77Ala) variant details
- p.Glu77Ala
- gnomAD rs1416732140
- Missense
- Variant Prioritization Score for Impact Estimate 0.389
- REVEL 0.18
- ESM-1b 1.00
- AlphaMissense 0.83
- MetaLR 0.08
- MetaSVM -1.06
- CADD 25.50
- Most common in the South Asian population (allele frequency 3e-05)
- Structural context available