A83T (p.Ala83Thr) variant of SHTN1 (Shootin-1)
A83T (p.Ala83Thr) in SHTN1 (Shootin-1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
A83T (p.Ala83Thr) variant details
- p.Ala83Thr
- NCI-TCGA Cosmic COSV5338
- cosmic curated COSV53382
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.746
- REVEL 0.63
- ESM-1b 1.00
- AlphaMissense 0.86
- MetaLR 0.86
- MetaSVM 0.62
- CADD 26.70
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:BANTUSOUTHAFRICA population (allele frequency 0.062)
- Structural context available