I24T (p.Ile24Thr) variant of SHMT2 (P34897)
I24T (p.Ile24Thr) in SHMT2 (P34897) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
I24T (p.Ile24Thr) variant details
- p.Ile24Thr
- cosmic curated COSV61074
- 1000Genomes rs138045473
- ExAC rs138045473
- TOPMed rs138045473
- Missense
- Variant Prioritization Score for Impact Estimate 0.104
- REVEL 0.10
- CADD 5.93
- PolyPhen-2 0.00
- SIFT 0.44
- Most common in the 1KG:ACB population (allele frequency 0.0054)
- Structural context available