I24L (p.Ile24Leu) variant of SHMT2 (P34897)
I24L (p.Ile24Leu) in SHMT2 (P34897) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
I24L (p.Ile24Leu) variant details
- p.Ile24Leu
- gnomAD rs2037284991
- Missense
- Variant Prioritization Score for Impact Estimate 0.0808
- REVEL 0.02
- AlphaMissense 0.08
- MetaLR 0.03
- MetaSVM -0.98
- CADD 0.08
- PolyPhen-2 0.00
- Most common in the HGDP:BANTUKENYA population (allele frequency 0.05)
- Structural context available