S63Y (p.Ser63Tyr) variant of SH2D1A (SH2 domain-containing protein 1A)
S63Y (p.Ser63Tyr) in SH2D1A (SH2 domain-containing protein 1A) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
S63Y (p.Ser63Tyr) variant details
- p.Ser63Tyr
- NCI-TCGA Cosmic COSV6357
- cosmic curated COSV63579
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.687
- REVEL 0.62
- MetaLR 0.91
- MetaSVM 0.80
- CADD 22.90
- PolyPhen-2 0.98
- SIFT 0.56
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available