I51T (p.Ile51Thr) variant of SH2D1A (SH2 domain-containing protein 1A)

I51T (p.Ile51Thr) in SH2D1A (SH2 domain-containing protein 1A) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of X-linked lymphoproliferative disease due to SH2D1A deficiency. The record also includes published literature and structural context.

I51T (p.Ile51Thr) variant details