T8S (p.Thr8Ser) variant of SERPINE1 (P05121)
T8S (p.Thr8Ser) in SERPINE1 (P05121) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
T8S (p.Thr8Ser) variant details
- p.Thr8Ser
- rs1156277677
- NCI-TCGA Cosmic COSV9977
- TOPMed rs1156277677
- gnomAD rs1156277677
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.408
- REVEL 0.22
- CADD 8.52
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available