H26R (p.His26Arg) variant of SERPINE1 (P05121)
H26R (p.His26Arg) in SERPINE1 (P05121) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
H26R (p.His26Arg) variant details
- p.His26Arg
- NCI-TCGA Cosmic COSV5616
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0979
- REVEL 0.12
- CADD 0.06
- PolyPhen-2 0.00
- SIFT 0.48
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available