G74R (p.Gly74Arg) variant of SERPINE1 (P05121)
G74R (p.Gly74Arg) in SERPINE1 (P05121) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
G74R (p.Gly74Arg) variant details
- p.Gly74Arg
- ExAC rs761071307
- TOPMed rs761071307
- gnomAD rs761071307
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.07
- CADD 17.60
- PolyPhen-2 0.18
- SIFT 0.13
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available