F186L (p.Phe186Leu) variant of SCN5A (Nav1.5)
F186L (p.Phe186Leu) in SCN5A (Nav1.5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 1.00 / 1. The record also includes structural context.
F186L (p.Phe186Leu) variant details
- p.Phe186Leu
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10034
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.996
- ESM-1b 1.00
- AlphaMissense 0.99
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available