T10A (p.Thr10Ala) variant of SCN10A (Nav1.8)
T10A (p.Thr10Ala) in SCN10A (Nav1.8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
T10A (p.Thr10Ala) variant details
- p.Thr10Ala
- gnomAD rs2064320166
- Missense
- Variant Prioritization Score for Impact Estimate 0.305
- REVEL 0.22
- MetaLR 0.74
- MetaSVM 0.14
- CADD 16.10
- PolyPhen-2 0.03
- SIFT 0.07
- Most common in the Middle Eastern population (allele frequency 0.00035)
- Structural context available