K65T (p.Lys65Thr) variant of SCN10A (Q9Y5Y9)
K65T (p.Lys65Thr) in SCN10A (Q9Y5Y9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
K65T (p.Lys65Thr) variant details
- p.Lys65Thr
- NCI-TCGA Cosmic COSV1014
- NCI-TCGA Cosmic COSV7186
- cosmic curated COSV71862
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.35
- REVEL 0.27
- MetaLR 0.66
- MetaSVM -0.11
- CADD 8.54
- PolyPhen-2 0.14
- SIFT 0.23
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available