F66S (p.Phe66Ser) variant of SCN10A (Q9Y5Y9)
F66S (p.Phe66Ser) in SCN10A (Q9Y5Y9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes population frequency data and structural context.
F66S (p.Phe66Ser) variant details
- p.Phe66Ser
- rs761786138
- NCI-TCGA Cosmic COSV7186
- cosmic curated COSV71862
- ExAC rs761786138
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.685
- REVEL 0.65
- MetaLR 0.84
- MetaSVM 0.89
- CADD 29.30
- PolyPhen-2 0.85
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Middle Eastern population (allele frequency 0.00069)
- Structural context available