V150A (p.Val150Ala) variant of SATB2 (DNA-binding protein SATB2)
V150A (p.Val150Ala) in SATB2 (DNA-binding protein SATB2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
V150A (p.Val150Ala) variant details
- p.Val150Ala
- NCI-TCGA Cosmic COSV9961
- cosmic curated COSV99610
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.578
- REVEL 0.45
- ESM-1b 1.00
- AlphaMissense 0.75
- CADD 24.30
- PolyPhen-2 0.81
- SIFT 0.15
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 7.6e-05)
- Structural context available