R88G (p.Arg88Gly) variant of SATB2 (DNA-binding protein SATB2)
R88G (p.Arg88Gly) in SATB2 (DNA-binding protein SATB2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
R88G (p.Arg88Gly) variant details
- p.Arg88Gly
- NCI-TCGA Cosmic COSV5348
- NCI-TCGA Cosmic COSV9961
- cosmic curated COSV99612
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- REVEL 0.40
- ESM-1b 1.00
- AlphaMissense 0.84
- CADD 27.90
- PolyPhen-2 0.73
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available