E98D (p.Glu98Asp) variant of SATB2 (DNA-binding protein SATB2)
E98D (p.Glu98Asp) in SATB2 (DNA-binding protein SATB2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
E98D (p.Glu98Asp) variant details
- p.Glu98Asp
- NCI-TCGA Cosmic COSV5348
- cosmic curated COSV53486
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.421
- REVEL 0.15
- ESM-1b 1.00
- AlphaMissense 0.97
- CADD 24.00
- PolyPhen-2 0.99
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available