S21P (p.Ser21Pro) variant of RNF215 (RING finger protein 215)
S21P (p.Ser21Pro) in RNF215 (RING finger protein 215) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
S21P (p.Ser21Pro) variant details
- p.Ser21Pro
- TOPMed rs1933616357
- Missense
- Variant Prioritization Score for Impact Estimate 0.194
- REVEL 0.15
- ESM-1b 0.00
- AlphaMissense 0.09
- CADD 17.50
- PolyPhen-2 0.02
- SIFT 1.00
- Most common in the HGDP:YORUBA population (allele frequency 0.048)
- Structural context available