P31L (p.Pro31Leu) variant of RNF215 (RING finger protein 215)
P31L (p.Pro31Leu) in RNF215 (RING finger protein 215) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
P31L (p.Pro31Leu) variant details
- p.Pro31Leu
- TOPMed rs1933615419
- Missense
- Variant Prioritization Score for Impact Estimate 0.33
- REVEL 0.14
- ESM-1b 0.00
- AlphaMissense 0.31
- CADD 23.20
- PolyPhen-2 0.91
- SIFT 1.00
- Most common in the 1KG:PUR population (allele frequency 0.0051)
- Structural context available