L26P (p.Leu26Pro) variant of RNF215 (RING finger protein 215)
L26P (p.Leu26Pro) in RNF215 (RING finger protein 215) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
L26P (p.Leu26Pro) variant details
- p.Leu26Pro
- Ensembl rs1601760977
- Missense
- Variant Prioritization Score for Impact Estimate 0.4
- REVEL 0.18
- ESM-1b 1.00
- AlphaMissense 0.24
- CADD 25.20
- PolyPhen-2 0.86
- SIFT 0.01
- Most common in the Ashkenazi Jewish population (allele frequency 0.00058)
- Structural context available