L26M (p.Leu26Met) variant of RNF215 (RING finger protein 215)
L26M (p.Leu26Met) in RNF215 (RING finger protein 215) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L26M (p.Leu26Met) variant details
- p.Leu26Met
- gnomAD rs1225145186
- Missense
- Variant Prioritization Score for Impact Estimate 0.262
- REVEL 0.05
- ESM-1b 1.00
- AlphaMissense 0.29
- CADD 22.60
- PolyPhen-2 0.86
- SIFT 0.02
- Most common in the HGDP:ADYGEI population (allele frequency 0.088)
- Structural context available