L23P (p.Leu23Pro) variant of RNF215 (RING finger protein 215)
L23P (p.Leu23Pro) in RNF215 (RING finger protein 215) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
L23P (p.Leu23Pro) variant details
- p.Leu23Pro
- TOPMed rs1933616216
- Missense
- Variant Prioritization Score for Impact Estimate 0.266
- REVEL 0.10
- ESM-1b 0.00
- AlphaMissense 0.14
- CADD 23.40
- PolyPhen-2 0.90
- SIFT 0.28
- Most common in the HGDP:DRUZE population (allele frequency 0.1)
- Structural context available