I90T (p.Ile90Thr) variant of RHEB (GTP-binding protein Rheb)
I90T (p.Ile90Thr) in RHEB (GTP-binding protein Rheb) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
I90T (p.Ile90Thr) variant details
- p.Ile90Thr
- gnomAD 7-151477339-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- REVEL 0.20
- MetaLR 0.18
- MetaSVM -0.88
- CADD 21.60
- PolyPhen-2 0.00
- SIFT 0.75
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available
- Literature evidence available