G13D (p.Gly13Asp) variant of RHEB (GTP-binding protein Rheb)
G13D (p.Gly13Asp) in RHEB (GTP-binding protein Rheb) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.86 / 1. The record also includes population frequency data and structural context.
G13D (p.Gly13Asp) variant details
- p.Gly13Asp
- NCI-TCGA Cosmic COSV1000
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.857
- REVEL 0.90
- MetaLR 0.98
- MetaSVM 1.02
- CADD 26.50
- PolyPhen-2 1.00
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available