V25L (p.Val25Leu) variant of RET (P07949)
V25L (p.Val25Leu) in RET (P07949) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.
V25L (p.Val25Leu) variant details
- p.Val25Leu
- gnomAD 10-43077331-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.391
- REVEL 0.19
- MetaLR 0.25
- MetaSVM -0.92
- CADD 24.60
- PolyPhen-2 0.01
- SIFT 0.82
- Population evidence available
- Structural context available
- Literature evidence available