L22P (p.Leu22Pro) variant of RET (P07949)
L22P (p.Leu22Pro) in RET (P07949) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data, published literature, and structural context.
L22P (p.Leu22Pro) variant details
- p.Leu22Pro
- gnomAD 10-43077323-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.627
- REVEL 0.56
- MetaLR 0.91
- MetaSVM 0.88
- CADD 24.70
- PolyPhen-2 0.38
- SIFT 0.09
- Population evidence available
- Structural context available
- Literature evidence available