L22I (p.Leu22Ile) variant of RET (P07949)
L22I (p.Leu22Ile) in RET (P07949) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
L22I (p.Leu22Ile) variant details
- p.Leu22Ile
- gnomAD 10-43077322-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.334
- REVEL 0.17
- MetaLR 0.86
- MetaSVM 0.60
- CADD 20.30
- PolyPhen-2 0.03
- SIFT 0.10
- Population evidence available
- Structural context available
- Literature evidence available