L21P (p.Leu21Pro) variant of RET (P07949)
L21P (p.Leu21Pro) in RET (P07949) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
L21P (p.Leu21Pro) variant details
- p.Leu21Pro
- gnomAD 10-43077320-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.655
- REVEL 0.56
- MetaLR 0.95
- MetaSVM 1.00
- CADD 29.90
- PolyPhen-2 0.98
- SIFT 0.10
- Population evidence available
- Structural context available
- Literature evidence available