L16L (p.Leu16Leu) variant of RET (P07949)
L16L (p.Leu16Leu) in RET (P07949) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
L16L (p.Leu16Leu) variant details
- p.Leu16Leu
- rs1309896929
- gnomAD 10-43077304-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.66
- AlphaMissense 0.08
- MetaLR 0.83
- MetaSVM 0.34
- CADD 12.90
- PolyPhen-2 0.01
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available
- Literature evidence available