L15F (p.Leu15Phe) variant of RET (P07949)
L15F (p.Leu15Phe) in RET (P07949) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
L15F (p.Leu15Phe) variant details
- p.Leu15Phe
- TOPMed rs876660157
- gnomAD rs876660157
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.459
- REVEL 0.24
- MetaLR 0.95
- MetaSVM 0.85
- CADD 23.40
- PolyPhen-2 0.86
- SIFT 0.79
- EBI: Likely benign
- UniProt: Likely benign
- Population evidence available
- Structural context available