R22C (p.Arg22Cys) variant of REL (Proto-oncogene c-Rel)
R22C (p.Arg22Cys) in REL (Proto-oncogene c-Rel) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes structural context.
R22C (p.Arg22Cys) variant details
- p.Arg22Cys
- rs372213094
- cosmic curated COSV54366
- ESP rs372213094
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.689
- AlphaMissense 1.00
- MetaLR 0.64
- MetaSVM 0.47
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available