K26E (p.Lys26Glu) variant of REL (Proto-oncogene c-Rel)
K26E (p.Lys26Glu) in REL (Proto-oncogene c-Rel) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
K26E (p.Lys26Glu) variant details
- p.Lys26Glu
- gnomAD 2-60891748-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.37
- REVEL 0.29
- MetaLR 0.16
- MetaSVM -0.98
- CADD 24.10
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available