I12L (p.Ile12Leu) variant of REL (Proto-oncogene c-Rel)
I12L (p.Ile12Leu) in REL (Proto-oncogene c-Rel) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
I12L (p.Ile12Leu) variant details
- p.Ile12Leu
- gnomAD 2-60891706-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.526
- REVEL 0.51
- MetaLR 0.51
- MetaSVM 0.20
- CADD 26.80
- PolyPhen-2 1.00
- SIFT 0.01
- Population evidence available
- Structural context available
- Literature evidence available