I10M (p.Ile10Met) variant of REL (Proto-oncogene c-Rel)
I10M (p.Ile10Met) in REL (Proto-oncogene c-Rel) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
I10M (p.Ile10Met) variant details
- p.Ile10Met
- rs753006954
- gnomAD 2-60891702-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.19
- REVEL 0.09
- MetaLR 0.14
- MetaSVM -0.95
- CADD 22.20
- PolyPhen-2 0.34
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available