S25T (p.Ser25Thr) variant of RAI1 (Retinoic acid-induced protein 1)
S25T (p.Ser25Thr) in RAI1 (Retinoic acid-induced protein 1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
S25T (p.Ser25Thr) variant details
- p.Ser25Thr
- rs891764320
- ClinGen CA288366761
- ClinVar RCV002197824
- ClinVar RCV003403675
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.14
- ESM-1b 0.00
- AlphaMissense 0.14
- CADD 22.10
- PolyPhen-2 0.16
- SIFT 0.00
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available