W8* (p.Trp8Ter) variant of RAF1 (P04049)
W8* (p.Trp8Ter) in RAF1 (P04049) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
W8* (p.Trp8Ter) variant details
- p.Trp8Ter
- gnomAD 14-20891796-G-A
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.581
- CADD 35.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.859
- Literature evidence available