V21I (p.Val21Ile) variant of RAF1 (P04049)
V21I (p.Val21Ile) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
V21I (p.Val21Ile) variant details
- p.Val21Ile
- rs751894020
- gnomAD 14-20891690-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.05
- MetaLR 0.04
- MetaSVM -1.04
- CADD 14.90
- PolyPhen-2 0.97
- SIFT 0.38
- Population evidence available
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.709
- Literature evidence available