V21F (p.Val21Phe) variant of RAF1 (P04049)
V21F (p.Val21Phe) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
V21F (p.Val21Phe) variant details
- p.Val21Phe
- rs751894020
- gnomAD 14-20891690-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.182
- REVEL 0.06
- MetaLR 0.04
- MetaSVM -1.04
- CADD 21.70
- PolyPhen-2 0.99
- SIFT 0.02
- Population evidence available
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.709
- Literature evidence available