T31M (p.Thr31Met) variant of RAF1 (P04049)
T31M (p.Thr31Met) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T31M (p.Thr31Met) variant details
- p.Thr31Met
- rs371809756
- gnomAD 14-20891784-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.351
- REVEL 0.26
- MetaLR 0.57
- MetaSVM -0.40
- CADD 21.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.391
- Literature evidence available