S12F (p.Ser12Phe) variant of RAF1 (P04049)
S12F (p.Ser12Phe) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S12F (p.Ser12Phe) variant details
- p.Ser12Phe
- gnomAD 14-20891709-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.164
- REVEL 0.09
- MetaLR 0.03
- MetaSVM -1.08
- CADD 17.10
- SIFT 0.02
- Most common in the HGDP:PIMA population (allele frequency 0.045)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.299
- Literature evidence available