R59W (p.Arg59Trp) variant of RAF1 (P04049)
R59W (p.Arg59Trp) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R59W (p.Arg59Trp) variant details
- p.Arg59Trp
- rs115812876
- gnomAD 14-20891849-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.282
- REVEL 0.31
- MetaLR 0.55
- MetaSVM -0.37
- CADD 11.90
- PolyPhen-2 0.95
- SIFT 0.02
- Most common in the 1KG:YRI population (allele frequency 0.0044)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.717
- Literature evidence available