R59Q (p.Arg59Gln) variant of RAF1 (P04049)
R59Q (p.Arg59Gln) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R59Q (p.Arg59Gln) variant details
- p.Arg59Gln
- rs760744021
- gnomAD 14-20891850-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.109
- REVEL 0.09
- MetaLR 0.15
- MetaSVM -1.00
- CADD 0.01
- PolyPhen-2 0.09
- SIFT 0.53
- Most common in the East Asian population (allele frequency 0.00058)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.717
- Literature evidence available