R59G (p.Arg59Gly) variant of RAF1 (P04049)
R59G (p.Arg59Gly) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R59G (p.Arg59Gly) variant details
- p.Arg59Gly
- rs183860442
- gnomAD 14-20891867-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.121
- REVEL 0.13
- MetaLR 0.03
- MetaSVM -1.06
- CADD 0.04
- PolyPhen-2 0.09
- SIFT 0.39
- Most common in the East Asian population (allele frequency 7.6e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.717
- Literature evidence available