M1Y (p.Met1Tyr) variant of RAF1 (P04049)
M1Y (p.Met1Tyr) in RAF1 (P04049) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
M1Y (p.Met1Tyr) variant details
- p.Met1Tyr
- gnomAD 14-20891738-C-CT
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.207
- CADD 17.80
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.369
- Literature evidence available