M1L (p.Met1Leu) variant of RAF1 (P04049)
M1L (p.Met1Leu) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
M1L (p.Met1Leu) variant details
- p.Met1Leu
- rs374635539
- gnomAD 14-20891741-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.0678
- REVEL 0.02
- MetaLR 0.00
- MetaSVM -1.01
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.369
- Literature evidence available