I58T (p.Ile58Thr) variant of RAF1 (P04049)
I58T (p.Ile58Thr) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I58T (p.Ile58Thr) variant details
- p.Ile58Thr
- rs1877566139
- gnomAD 14-20891841-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.102
- REVEL 0.07
- MetaLR 0.14
- MetaSVM -0.87
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 0.93
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.361
- Literature evidence available