I32M (p.Ile32Met) variant of RAF1 (P04049)
I32M (p.Ile32Met) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
I32M (p.Ile32Met) variant details
- p.Ile32Met
- rs767807631
- gnomAD 14-20891806-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.276
- REVEL 0.26
- MetaLR 0.46
- MetaSVM -0.54
- CADD 13.50
- PolyPhen-2 0.67
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available
- Literature evidence available