I32F (p.Ile32Phe) variant of RAF1 (P04049)
I32F (p.Ile32Phe) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, published literature, and structural context.
I32F (p.Ile32Phe) variant details
- p.Ile32Phe
- rs760867669
- gnomAD 14-20891813-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.229
- REVEL 0.22
- MetaLR 0.43
- MetaSVM -0.51
- CADD 12.60
- PolyPhen-2 0.78
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available
- Literature evidence available