I11M (p.Ile11Met) variant of RAF1 (P04049)
I11M (p.Ile11Met) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I11M (p.Ile11Met) variant details
- p.Ile11Met
- rs752773252
- gnomAD 14-20891716-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.109
- REVEL 0.04
- MetaLR 0.03
- MetaSVM -1.04
- CADD 12.90
- PolyPhen-2 0.74
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.5e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.63
- Literature evidence available