G16R (p.Gly16Arg) variant of RAF1 (P04049)
G16R (p.Gly16Arg) in RAF1 (P04049) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
G16R (p.Gly16Arg) variant details
- p.Gly16Arg
- rs867802498
- gnomAD 14-20891735-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.16
- MetaLR 0.07
- MetaSVM -1.11
- CADD 23.00
- PolyPhen-2 1.00
- SIFT 0.05
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.417
- Literature evidence available