F36L (p.Phe36Leu) variant of RAF1 (P04049)
F36L (p.Phe36Leu) in RAF1 (P04049) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
F36L (p.Phe36Leu) variant details
- p.Phe36Leu
- rs770621900
- gnomAD 14-20891797-GT-G
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.445
- CADD 24.10
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- RAF1 Raf-like Ras-binding domain domainome 1.0: score -0.167
- Literature evidence available